Description

2-(Trifluoromethyl)Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid is a high-value heterocyclic building block featuring a fused imidazopyrimidine core functionalized with a carboxylic acid and a trifluoromethyl group. This compound matters for its unique structural motifs, which are critical for modulating the physicochemical and biological properties of advanced molecules in pharmaceutical research. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Chemical Biology Probe Development: Serves as a core scaffold for creating tool compounds to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of specialty polymers or organic electronic materials due to its conjugated heterocyclic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions for clinical trials.

Basic Information

Product Name	2-(Trifluoromethyl)Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid
CAS No.	866149-90-8
Molecular Formula	C8H4F3N3O2
Molecular Weight	231.14 g/mol
Synonyms	2-(Trifluoromethyl)imidazo[1,2-a]pyrimidine-3-carboxylic acid; Imidazo[1,2-a]pyrimidine-3-carboxylic acid, 2-(trifluoromethyl)-; 866149-90-8; 2-Trifluoromethyl-imidazo[1,2-a]pyrimidine-3-carboxylic acid; 2-(Trifluoromethyl)-3-imidazo[1,2-a]pyrimidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.