Description

Ethyl 4-(Trifluoromethyl)-2-(Pyridin-2-Yl)Pyrimidine-5-Carboxylate is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its trifluoromethyl and pyrimidine-pyridine hybrid structure, which is critical for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a building block for creating specialized organic electronic materials and ligands for catalysis.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	Ethyl 4-(Trifluoromethyl)-2-(Pyridin-2-Yl)Pyrimidine-5-Carboxylate
CAS No.	866132-66-3
Molecular Formula	C13H10F3N3O2
Molecular Weight	297.24 g/mol
Synonyms	Ethyl 4-(trifluoromethyl)-2-(2-pyridinyl)-5-pyrimidinecarboxylate; 5-Pyrimidinecarboxylic acid, 4-(trifluoromethyl)-2-(2-pyridinyl)-, ethyl ester; 2-Pyridyl-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-trifluoromethyl-2-(pyridin-2-yl)pyrimidine-5-carboxylate; 866132-66-3; 4-(Trifluoromethyl)-2-(2-pyridinyl)-5-pyrimidinecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(Trifluoromethyl)-2-(Pyridin-2-Yl)Pyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.