Description

3',5'-Difluoro-Biphenyl-3-Amine is a high-purity, fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its molecular structure, featuring a biphenyl core with strategically placed fluorine and amine groups, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and production chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An essential reagent for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis, particularly in cross-coupling reactions critical for forming carbon-carbon and carbon-heteroatom bonds.

Basic Information

Product Name	3',5'-Difluoro-Biphenyl-3-Amine
CAS No.	866108-74-9
Molecular Formula	C12H9F2N
Molecular Weight	205.20 g/mol
Synonyms	3-Amino-3',5'-difluorobiphenyl; [1,1'-Biphenyl]-3-amine, 3',5'-difluoro-; 3',5'-Difluoro-[1,1'-biphenyl]-3-amine; 3-(3,5-Difluorophenyl)aniline; 3-Amino-3',5'-difluoro-1,1'-biphenyl
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoro-Biphenyl-3-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.