Description

Fmoc-Glu(Otbu)-Gly-OH is a protected dipeptide building block widely used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise control. It is an essential raw material for the pharmaceutical, biotechnology, and research sectors, particularly in the development of therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of peptide chains on resin.
• Therapeutic Peptide Development: Used in the research and GMP production of peptide-based drugs targeting metabolic disorders, oncology, and other therapeutic areas.
• Bioconjugation and Probe Synthesis: Serves as a component for creating labeled peptides used in diagnostic assays and imaging studies.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Academic and Industrial Research: A fundamental reagent for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-Glu(Otbu)-Gly-OH
CAS No.	866044-63-5
Molecular Formula	C26H30N2O7
Molecular Weight	482.53 g/mol
Synonyms	Fmoc-Glu(OtBu)-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-tert-butyl ester-glycine; Fmoc-L-Glutamic acid 5-tert-butyl ester-glycine; Fmoc-Glu(OtBu)-Gly; Nα-Fmoc-Nγ-tert-butyl-L-glutamyl-glycine; Fmoc-Glu(OtBu)-Glycine; Fmoc-Glu(OtBu)-Gly-OH Peptide Building Block; (2S)-5-[[(2-Methylpropan-2-yl)oxy]-5-oxo-2-[[2-[(9H-fluoren-9-ylmethoxy)formamido]acetyl]amino]pentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Otbu)-Gly-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability for research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.