Description

2-[(6-Chloro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Methyl]Benzonitrile is a high-purity, synthetically valuable pyrimidine derivative, serving as a critical pharmaceutical intermediate and research chemical. Its molecular structure makes it a versatile building block for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer research. This compound is essential for R&D laboratories, process chemists, and manufacturers in the fine chemical and pharmaceutical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analogs and other pyrimidine-based therapeutic agents.
• Antiviral Drug Research: Used in the research and development of potential antiviral compounds targeting viral polymerases.
• Oncology Research: Serves as a precursor in the development of small molecule inhibitors and targeted cancer therapies.
• Chemical Biology: Employed as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for complex organic molecules in pilot plants.
• Fine Chemical Synthesis: A versatile intermediate for creating specialized dyes, agrochemicals, and other high-value chemicals.

Basic Information

Product Name	2-[(6-Chloro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Methyl]Benzonitrile
CAS No.	865758-95-8
Molecular Formula	C₁₂H₈ClN₃O₂
Molecular Weight	261.66 g/mol
Synonyms	1-[(2-Cyanophenyl)methyl]-6-chloro-2,4(1H,3H)-pyrimidinedione; 6-Chloro-1-[(2-cyanobenzyl)]uracil; 1-(2-Cyanobenzyl)-6-chlorouracil; 6-Chloro-1-(2-cyanobenzyl)pyrimidine-2,4(1H,3H)-dione; 2-[(6-Chloro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)methyl]benzonitrile; 6-Chloro-1-(2-cyanobenzyl)uracil; Uracil, 6-chloro-1-[(2-cyanophenyl)methyl]-; 865758-95-8
EINECS	Contact for details

Quality Control

Our 2-[(6-Chloro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Methyl]Benzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.