Description

D-Norleucine, 1-(Methoxycarbonyl)-D-Tryptophyl-, (4-Nitrophenyl)Methyl Ester, Monohydrochloride (9Ci) is a specialized, high-purity synthetic peptide derivative used as a critical building block in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of complex peptide-based molecules, where its specific stereochemistry and protected functional groups are essential. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology industries for drug discovery, process development, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of potential peptide-based active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new chemical entities.
• Process Chemistry & Scale-up: Serves as a defined intermediate in the development and optimization of scalable synthetic routes for candidate drugs.
• Biochemical Research: Employed in the study of enzyme-substrate interactions and the synthesis of custom peptides for biological assays.
• Protecting Group Chemistry: The specific ester and carbamate protecting groups make it a valuable tool in complex, orthogonal synthetic strategies.

Basic Information

Product Name	D-Norleucine, 1-(Methoxycarbonyl)-D-Tryptophyl-, (4-Nitrophenyl)Methyl Ester, Monohydrochloride (9Ci)
CAS No.	865488-40-0
Molecular Formula	C25H28N4O6 • HCl
Molecular Weight	517.98 g/mol (free base: 480.52 g/mol)
Synonyms	1-[(Methoxycarbonyl)-D-tryptophyl]-D-norleucine 4-Nitrobenzyl Ester Hydrochloride; D-Nle-1-MeOCO-D-Trp-ONbz • HCl; (4-Nitrophenyl)methyl 1-[(methoxycarbonyl)-D-tryptophyl]-D-norleucinate hydrochloride; Fmoc-D-Trp(Boc)-D-Nle-OBzl(4-NO2) precursor derivative; Protected D-Tryptophan-D-Norleucine dipeptide ester hydrochloride
EINECS	Contact for details

Quality Control

This high-grade synthetic intermediate is produced under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.