Description

1-(4-Bromophenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4(5H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is a critical building block in medicinal chemistry, valued for its role in the synthesis of targeted kinase inhibitors and other bioactive molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for oncology, inflammation, and autoimmune diseases.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities in drug discovery programs.
• Biochemical Tool Compound: Serves as a reference standard or a starting material for developing assay probes to study specific enzyme functions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-(4-Bromophenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4(5H)-One
CAS No.	864872-05-9
Molecular Formula	C11H7BrN4O
Molecular Weight	291.10 g/mol
Synonyms	4(5H)-One, 1-(4-Bromophenyl)-1H-pyrazolo[3,4-d]pyrimidin-; 1-(4-Bromophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 1-(4-Bromophenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one; 1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one, 1-(4-bromophenyl)-; BMS-5; BMS 5; BMS5
EINECS	Contact for details

Quality Control

Our production of 1-(4-Bromophenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4(5H)-One adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support development and commercial projects with material suitable for research use through to cGMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.