Description

2,4-Dichloro-7-Cyanoquinazoline is a high-value, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its dual reactive sites—the chlorine atoms and the cyano group—which allow for selective and sequential functionalization, enabling the rapid construction of complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted cancer therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the quinazoline scaffold's bioactivity.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating tool compounds to study enzyme function and signal transduction pathways.
• Material Science Research: Investigated as a building block for organic electronic materials and metal-organic frameworks (MOFs) due to its planar, conjugated structure.
• Custom Synthesis & Contract Manufacturing: Employed in the production of bespoke fine chemicals and advanced intermediates for client-specific R&D projects.

Basic Information

Item	Detail
Product Name	2,4-Dichloro-7-Cyanoquinazoline
CAS No.	864292-40-0
Molecular Formula	C9H3Cl2N3
Molecular Weight	224.05 g/mol
Synonyms	7-Cyano-2,4-dichloroquinazoline; 2,4-Dichloro-7-quinazolinecarbonitrile; 2,4-Dichloroquinazoline-7-carbonitrile; Quinazoline, 2,4-dichloro-7-cyano-; 864292-40-0; AKOS005258155; BDBM50382889; ZINC000003869756
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dichloro-7-Cyanoquinazoline is produced under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are supplied with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.