Description

1-[2-(Trifluoromethoxy)Phenyl]Ethan-1-Amine is a specialized aromatic amine building block featuring a trifluoromethoxy substituent, which imparts unique electronic and steric properties. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical agents. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for constructing complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1-[2-(Trifluoromethoxy)Phenyl]Ethan-1-Amine
CAS No.	864263-88-7
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	1-[2-(Trifluoromethoxy)phenyl]ethanamine; α-Methyl-2-(trifluoromethoxy)benzylamine; 2-(Trifluoromethoxy)phenethylamine, α-methyl-; 1-(2-Trifluoromethoxyphenyl)ethylamine; 2-(Trifluoromethoxy)α-methylbenzeneethanamine
EINECS	Contact for details

Quality Control

Our production of 1-[2-(Trifluoromethoxy)Phenyl]Ethan-1-Amine adheres to stringent quality management protocols. Every batch is analyzed using advanced chromatographic and spectroscopic techniques to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality system is designed to support cGMP compliance for pharmaceutical applications and meets the rigorous standards required for global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.