Description

Opiorphin is a potent, naturally occurring pentapeptide with significant biological activity, identified by the CAS registry number 864084-88-8. This compound is valued for its role as a dual inhibitor of neutral endopeptidase and aminopeptidase N, offering a unique mechanism of action for research and development. It is primarily sought by researchers and developers in the pharmaceutical and biotechnology sectors for applications in pain management, neurological studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: As a lead compound for developing new classes of non-opioid analgesic drugs targeting enkephalinase inhibition.
• Neuroscience Studies: Investigation of endogenous pain modulation pathways and the role of enkephalins in the central nervous system.
• Biochemical Assay Development: Used as a standard or inhibitor in enzymatic assays for neutral endopeptidase (NEP) and aminopeptidase N (APN).
• Preclinical Studies: Evaluation of efficacy and pharmacokinetics in animal models for pain, depression, and anxiety.
• Peptide Chemistry Reference: Serves as a reference standard in analytical method development and quality control for peptide-based pharmaceuticals.

Basic Information

Product Name	Opiorphin
CAS No.	864084-88-8
Molecular Formula	C27H40N8O8
Molecular Weight	604.66 g/mol
Synonyms	QRFPR; Gln-Arg-Phe-Pro-Arg; Pentapeptide QRFPR; Human opiorphin; Salivary opiorphin; Opiorphin (human); 1-(N-α-L-glutaminyl)-5-(N-ω-N-ω'-bis(N-α-L-arginyl)-L-arginyl)-L-phenylalanyl-L-prolyl-L-arginine
EINECS	Contact for details

Quality Control

Our Opiorphin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by mass spectrometry and HPLC for purity assessment, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.