Description

2(1H)-Pyrimidinone, 1-[(2S)-2-Hydroxy-3-(Triphenylmethoxy)Propyl]-4-[[(4-Methoxyphenyl)Diphenylmethyl]Amino]- is a sophisticated, high-purity nucleoside analog intermediate designed for advanced pharmaceutical synthesis. This compound is critical for researchers and manufacturers developing next-generation antiviral and anticancer therapeutics, where precise molecular structure and chiral purity are paramount. It is primarily utilized by fine chemical suppliers and R&D departments within the pharmaceutical and biotechnology industries for the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Protease Inhibitor Research: Used in the development and scale-up of protease inhibitors for treating viral infections.
• Antiretroviral Drug Development: Serves as a critical precursor in the manufacturing chain for HIV and HCV therapeutics.
• Chiral Synthesis: Exploited in asymmetric synthesis due to its defined (2S) stereochemistry for creating enantiomerically pure compounds.
• Bioconjugation & Prodrug Development: The functional groups allow for targeted bioconjugation strategies in prodrug design.
• Chemical Biology & Target Identification: Used as a molecular probe to study enzyme mechanisms and identify new biological targets.

Basic Information

Item	Details
Product Name	2(1H)-Pyrimidinone, 1-[(2S)-2-Hydroxy-3-(Triphenylmethoxy)Propyl]-4-[[(4-Methoxyphenyl)Diphenylmethyl]Amino]-
CAS No.	864068-43-9
Molecular Formula	C40H37N3O4
Molecular Weight	623.75 g/mol
Synonyms	1-[(2S)-2-Hydroxy-3-(Triphenylmethoxy)Propyl]-4-[[(4-Methoxyphenyl)Diphenylmethyl]Amino]-2(1H)-Pyrimidinone; 4-[[Bis(4-methoxyphenyl)phenylmethyl]amino]-1-[(2S)-2-hydroxy-3-(trityloxy)propyl]pyrimidin-2(1H)-one; (2S)-1-[4-[[Bis(4-methoxyphenyl)phenylmethyl]amino]-2-oxopyrimidin-1-yl]-3-(trityloxy)propan-2-ol; Nucleoside analog intermediate with Trt and DMT protecting groups; Advanced pharmaceutical intermediate CAS 864068-43-9.
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced under strict cGMP-compliant conditions and subjected to a comprehensive battery of analytical tests. Our quality assurance protocol ensures exceptional chiral purity and chemical identity, critical for downstream pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, impurity profile, and confirming compliance with client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.