Description

2-Amino-4-(trifluoromethyl)pyrimidine-5-carbaldehyde is a high-value, multi-functional heterocyclic building block characterized by its reactive aldehyde group and electron-deficient pyrimidine core. This compound matters for its critical role as a key synthetic intermediate in the development of advanced pharmaceuticals and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for metal-catalyzed reactions and organocatalysts due to its nitrogen-rich, chelating structure.
• Material Science Research: Acts as a building block for organic electronic materials, such as those used in OLEDs or conductive polymers, where its planar, conjugated system is advantageous.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up campaigns in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	2-Amino-4-(trifluoromethyl)pyrimidine-5-carbaldehyde
CAS No.	863774-22-5
Molecular Formula	C6H4F3N3O
Molecular Weight	191.11 g/mol
Synonyms	5-Formyl-2-amino-4-(trifluoromethyl)pyrimidine; 2-Amino-4-trifluoromethyl-5-pyrimidinecarboxaldehyde; 4-(Trifluoromethyl)-2-amino-5-pyrimidinecarbaldehyde; 2-Amino-4-(trifluoromethyl)-5-pyrimidinecarboxaldehyde; 2-Amino-4-(trifluoromethyl)pyrimidine-5-carboxaldehyde; 5-Pyrimidinecarboxaldehyde, 2-amino-4-(trifluoromethyl)-; 2-Amino-4-trifluoromethylpyrimidine-5-carbaldehyde
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(trifluoromethyl)pyrimidine-5-carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and may be sensitive to moisture; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.