Description

(2'R)-2'-Deoxy-2'-Fluoro-2'-Methyl-Uridine 3',5'-Dibenzoate is a high-purity, protected nucleoside derivative, a critical building block in advanced pharmaceutical synthesis. Its value lies in its role as a key synthetic intermediate for the development of modified oligonucleotides, including antisense and siRNA therapeutics, where the 2'-fluoro-2'-methyl modification enhances stability and target affinity. This compound is essential for research institutions and pharmaceutical companies engaged in the discovery and production of next-generation nucleic acid-based drugs and diagnostic probes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of modified nucleosides and nucleotides for therapeutic applications.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate 2'-fluoro-2'-methyl modifications into oligonucleotide chains to improve nuclease resistance and binding affinity.
• siRNA (Small Interfering RNA) Production: Serves as a building block for creating stabilized siRNA strands with enhanced pharmacokinetic properties.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop novel antiviral and anticancer agents.
• Diagnostic Probe Development: Utilized in the creation of labeled nucleic acid probes for molecular diagnostics and imaging.
• Bioconjugation: The benzoate protecting groups offer handles for further chemical modification and conjugation to delivery systems.

Basic Information

Product Name	(2'R)-2'-Deoxy-2'-Fluoro-2'-Methyl-Uridine 3',5'-Dibenzoate
CAS No.	863329-65-1
Molecular Formula	C24H21FN2O7
Molecular Weight	468.43 g/mol
Synonyms	1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl)uracil; 2'-Deoxy-2'-fluoro-2'-C-methyluridine 3',5'-dibenzoate; (2R)-2'-Deoxy-2'-fluoro-2'-C-methyluridine 3',5'-dibenzoate; 2'-F-2'-Me-Uridine 3',5'-dibenzoate; PSI-6130 intermediate (protected); β-D-3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-2'-C-methyluridine; 863329-65-1
EINECS	Contact for details

Quality Control

Our (2'R)-2'-Deoxy-2'-Fluoro-2'-Methyl-Uridine 3',5'-Dibenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.