Description

3-Bromo-1-tert-Butyl-1H-Pyrazolo-[3,4-D]Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of targeted kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutics for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new drug candidates.
• Biochemical Tool Compound: Serves as a reference standard or a starting material for creating labeled probes in biochemical and pharmacological assays.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	3-Bromo-1-tert-Butyl-1H-Pyrazolo-[3,4-D]Pyrimidin-4-Amine
CAS No.	862728-61-8
Molecular Formula	C9H12BrN5
Molecular Weight	270.13 g/mol
Synonyms	3-Bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-(1,1-Dimethylethyl)-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-Bromo-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine; 862728-61-8; tert-Butyl 3-bromo-4-aminopyrazolo[3,4-d]pyrimidine-1-carboxylate (precursor related); 3-Bromo-1-(tert-butyl)-4-aminopyrazolo[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-1-tert-Butyl-1H-Pyrazolo-[3,4-D]Pyrimidin-4-Amine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this light-sensitive compound. Store away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.