Description

3-(Aminomethyl)-5-(Trifluoromethyl)Phenol is a versatile trifluoromethyl and aminomethyl-substituted phenolic compound, serving as a key multifunctional building block in advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group with an aminomethyl linker and a highly stable trifluoromethyl group, makes it invaluable for creating molecules with tailored properties. This intermediate is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists exploring advanced polymers and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the phenolic and aminomethyl functionalities allow for the creation of compounds with specific modes of action.
• Ligand and Catalyst Development: Serves as a scaffold for constructing chelating ligands in catalysis and metal-organic frameworks (MOFs) due to its phenolic and amine donor sites.
• Polymer Modification: Acts as a monomer or cross-linking agent for producing high-performance polymers, resins, and coatings with enhanced chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A valuable building block in medicinal and combinatorial chemistry for creating diverse compound libraries for high-throughput screening.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where the trifluoromethyl group can influence color fastness and solubility.

Basic Information

Product Name	3-(Aminomethyl)-5-(Trifluoromethyl)Phenol
CAS No.	862541-22-8
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	5-(Trifluoromethyl)-3-(aminomethyl)phenol; 3-(Aminomethyl)-5-(trifluoromethyl)benzenol; 3-(Aminomethyl)-α,α,α-trifluoro-m-cresol; 3-Hydroxy-5-(trifluoromethyl)benzylamine; 3-(Trifluoromethyl)-5-hydroxybenzylamine; m-(Trifluoromethyl)-m-hydroxybenzylamine; 862541-22-8; 3-Aminomethyl-5-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our production of 3-(Aminomethyl)-5-(Trifluoromethyl)Phenol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets precise customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We are committed to consistent purity, reliable supply, and full traceability to support your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.