Description

7-Difluoromethyl-5-Phenyl-Pyrazolo[1,5-A]Pyrimidine-3-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its pyrazolopyrimidine core and acid chloride functionality. This compound is essential for the synthesis of advanced pharmaceutical agents and agrochemicals, where it serves as a key building block for introducing complex heterocyclic scaffolds. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors, anti-cancer agents, and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Synthesis: Used in the development of next-generation fungicides and herbicides, leveraging its difluoromethyl and heterocyclic structure for enhanced bioactivity and environmental profile.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials, such as ligands for catalysts or components for organic electronics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and clinical trial materials.

Basic Information

Product Name	7-Difluoromethyl-5-Phenyl-Pyrazolo[1,5-A]Pyrimidine-3-Carbonyl Chloride
CAS No.	861412-81-9
Molecular Formula	C14H8ClF2N3O
Molecular Weight	307.68 g/mol
Synonyms	7-(Difluoromethyl)-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl chloride; 5-Phenyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride; Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride, 7-(difluoromethyl)-5-phenyl-; 861412-81-9; 7-Difluoromethyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 7-Difluoromethyl-5-Phenyl-Pyrazolo[1,5-A]Pyrimidine-3-Carbonyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.