Description

(1S,3R,4R,7R)-7-Benzyloxy-1-(Hydroxymethyl)-3-(Thymin-1-Yl)-2,5-Dioxabicyclo[2.2.1]Heptane CAS NO 861230-75-3 is a sophisticated nucleoside analog building block, characterized by its bicyclic structure and thymine base. This compound is of significant value as a key intermediate in the synthesis of modified oligonucleotides and nucleotide-based therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antisense drugs, diagnostic probes, and novel antiviral agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of modified nucleosides and nucleotide prodrugs.
• Antisense Oligonucleotide (ASO) Research: Used to incorporate modified sugar moieties into oligonucleotide sequences to enhance stability and binding affinity.
• Pro-Nucleotide (ProTide) Chemistry: Serves as a precursor in the development of phosphoramidate prodrugs for improved cellular delivery of nucleoside monophosphates.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies for novel antiviral and anticancer agents targeting viral polymerases or cellular DNA/RNA.
• Diagnostic Probe Development: Utilized in creating labeled nucleotide analogs for use in molecular diagnostics and imaging.
• Bioconjugation: The hydroxymethyl group provides a handle for further chemical modification and linkage to carriers or other molecules.

Basic Information

Item	Details
Product Name	(1S,3R,4R,7R)-7-Benzyloxy-1-(Hydroxymethyl)-3-(Thymin-1-Yl)-2,5-Dioxabicyclo[2.2.1]Heptane
CAS No.	861230-75-3
Molecular Formula	C18H20N2O6
Molecular Weight	360.36 g/mol
Synonyms	7-Benzyloxy-1-(hydroxymethyl)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane; 1-(Hydroxymethyl)-7-benzyloxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane; Bicyclic Thymidine Derivative; Locked Nucleic Acid (LNA) Precursor Analog; Nucleoside Bicyclic Intermediate; 1,3-Dioxolane-fused Nucleoside; Benzyl-protected nucleoside synthon
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.