Description

(5-Cyano-Pyrimidin-2-Yl)-Methyl-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected carbamate and a cyano-substituted pyrimidine core. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of targeted cancer therapies and other specialized medicinal compounds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel kinase inhibitors and other targeted small-molecule therapeutics.
• Oncology Drug Development: Serves as a critical precursor in the research and manufacturing of investigational anti-cancer agents.
• Chemical Research: Used in academic and industrial R&D for exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for API manufacturing under cGMP conditions.
• Custom Synthesis: A starting material for the preparation of more complex, functionalized pyrimidine derivatives for specialized applications.

Basic Information

Product Name	(5-Cyano-Pyrimidin-2-Yl)-Methyl-Carbamic Acid tert-Butyl Ester
CAS No.	861144-33-4
Molecular Formula	C12H16N4O2
Molecular Weight	248.28 g/mol
Synonyms	tert-Butyl N-[(5-cyanopyrimidin-2-yl)methyl]carbamate; N-[(5-Cyanopyrimidin-2-yl)methyl]carbamic Acid tert-Butyl Ester; 2-[[(tert-Butoxycarbonyl)amino]methyl]pyrimidine-5-carbonitrile; BOC-Protected 5-Cyanopyrimidin-2-ylmethylamine; (5-Cyano-2-pyrimidinyl)methylcarbamic Acid 1,1-Dimethylethyl Ester
EINECS	Contact for details

Quality Control

Our (5-Cyano-Pyrimidin-2-Yl)-Methyl-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.