Description

Uracil, 5-Amino-3-Ethyl (1Ci) is a specialized, isotopically labeled derivative of the uracil nucleobase, featuring an ethyl group at the 3-position and an amino group at the 5-position. This compound is of significant value in advanced research and development, particularly as a key building block for synthesizing labeled nucleosides, nucleotides, and oligonucleotides. It is primarily needed by pharmaceutical R&D teams, agrochemical researchers, and academic institutions engaged in metabolic pathway tracing, pharmacokinetic studies, and the development of novel diagnostic probes.

Application

• Isotopic Tracer in Metabolism Studies: Used as a carbon-13 labeled precursor to track the incorporation and fate of uracil derivatives in biological systems.
• Pharmaceutical Intermediate: Serves as a critical synthon in the research and development of novel antiviral and anticancer nucleoside analogs.
• Agrochemical Research: Employed in the synthesis of labeled compounds for studying the environmental fate and metabolic pathways of agrochemicals.
• Diagnostic Probe Development: Utilized to create labeled molecules for use in advanced imaging techniques like PET (Positron Emission Tomography) or as internal standards in LC-MS/MS assays.
• Biochemical Research: Acts as a tool compound for investigating enzyme mechanisms involving uracil metabolism, such as in studies of dihydropyrimidine dehydrogenase (DPD).
• Standards for Analytical Chemistry: Provides a high-purity, isotopically labeled standard for quantitative mass spectrometry, ensuring accurate measurement in complex matrices.

Basic Information

Product Name	Uracil, 5-Amino-3-Ethyl (1Ci)
CAS No.	860574-41-0
Molecular Formula	C6H913CN3O2
Molecular Weight	Contact for details
Synonyms	5-Amino-3-ethyluracil-1-13C; 3-Ethyl-5-aminouracil-1-13C; 5-Amino-3-ethyl-1-13C-uracil; 5-Amino-3-ethyl-2,4(1H,3H)-pyrimidinedione-1-13C; 1-13C-5-Amino-3-ethyluracil; [1-13C]-5-Amino-3-ethyluracil; Labeled 5-Amino-3-ethyluracil
EINECS	Contact for details

Quality Control

Every batch of Uracil, 5-Amino-3-Ethyl (1Ci) is produced and analyzed under strict quality management systems. We employ advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to verify chemical identity, isotopic enrichment, and purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, radiochemical purity, and solvent residues is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when possible to maintain purity and isotopic integrity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 98%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.