Description

Fmoc-(S)-2-Aminohex-4-Ynoic Acid is a specialized, non-proteinogenic amino acid derivative featuring an alkyne functional group. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the site-specific introduction of bioorthogonal handles for conjugation and labeling. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and chemical probes. The molecule's unique structure allows for further functionalization via click chemistry, making it invaluable for advanced bioconjugation strategies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of peptides containing non-natural amino acids.
• Bioconjugation & Labeling: The alkyne side chain serves as a bioorthogonal handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC) to attach fluorophores, biotin, or other functional moieties.
• Peptidomimetic Drug Discovery: Used to create peptide analogs with enhanced stability, bioavailability, or target affinity for therapeutic candidate screening.
• Chemical Biology Probes: Incorporation into peptides to create activity-based probes for studying enzyme function and protein-protein interactions.
• Material Science: Potential use in the synthesis of functionalized polymers or surfaces for biosensor applications.

Basic Information

Product Name	Fmoc-(S)-2-Aminohex-4-Ynoic Acid
CAS No.	859841-96-6
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38 g/mol
Synonyms	Fmoc-(S)-2-Amino-4-hexynoic Acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hex-4-ynoic Acid; Fmoc-Ahx(4-yn)-OH; N-α-Fmoc-S-2-amino-4-hexynoic acid; Fmoc-L-2-Aminohex-4-ynoic Acid; N-Fmoc-L-2-amino-4-hexynoic acid; Fmoc-L-4-hexynoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Aminohex-4-Ynoic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.