Description

2-Amino-7-Benzyl-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4(4Ah)-One is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the research and development of novel therapeutic agents, particularly kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted drug candidates, especially within oncology and CNS research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing potent, selective kinase inhibitors due to its pyridopyrimidine structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities for various disease targets.
• Biochemical Assay Standards: Employed as a reference standard or ligand in high-throughput screening and biochemical assays.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client-specific drug discovery programs.

Basic Information

Product Name	2-Amino-7-Benzyl-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4(4Ah)-One
CAS No.	859825-77-7
Molecular Formula	C₁₆H₁₈N₄O
Molecular Weight	282.34 g/mol
Synonyms	2-Amino-7-benzyl-4,5,6,7-tetrahydro-4H-pyrido[3,4-d]pyrimidin-4-one; 7-Benzyl-2-amino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one; 2-Amino-7-benzyl-4a,5,6,7,8,8a-hexahydro-4H-pyrido[3,4-d]pyrimidin-4-one; CAS 859825-77-7; Pyrido[3,4-d]pyrimidin-4(4aH)-one, 2-amino-7-benzyl-5,6,7,8-tetrahydro-; 2-Amino-7-benzyl-4a,5,6,7,8,8a-hexahydro-4H-pyrido[3,4-d]pyrimidin-4-one
EINECS	Contact for details

Quality Control

Our 2-Amino-7-Benzyl-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4(4Ah)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.