Description

6-Amino-5-Chloro-2-Cyclopropyl-Pyrimidine-4-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a distinct pyrimidine core structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging its chlorinated pyrimidine scaffold for biological activity.
• Chemical Synthesis Building Block: Serves as a versatile substrate for further functionalization, including hydrolysis, amidation, and cross-coupling reactions to create diverse chemical libraries.
• Material Science Research: Investigated for potential use in the development of organic electronic materials and metal-organic frameworks (MOFs) due to its nitrogen-rich heterocyclic structure.

Basic Information

Product Name	6-Amino-5-Chloro-2-Cyclopropyl-Pyrimidine-4-Carboxylic Acid Ethyl Ester
CAS No.	858954-79-7
Molecular Formula	C10H12ClN3O2
Molecular Weight	241.67 g/mol
Synonyms	Ethyl 6-Amino-5-Chloro-2-Cyclopropylpyrimidine-4-Carboxylate; 6-Amino-5-Chloro-2-Cyclopropyl-4-Pyrimidinecarboxylic Acid Ethyl Ester; 5-Chloro-2-Cyclopropyl-6-Aminopyrimidine-4-Carboxylic Acid Ethyl Ester; ACCPE; 858954-79-7; 6-Amino-5-chloro-2-cyclopropyl-pyrimidine-4-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of 6-Amino-5-Chloro-2-Cyclopropyl-Pyrimidine-4-Carboxylic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA), detailing results from HPLC, NMR, and other analytical methods, is provided with each shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.