Description

7-Chloro-6-Methoxyquinazolin-4(3H)-One is a high-purity quinazolinone derivative, a crucial advanced pharmaceutical intermediate. This compound matters for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers focused on oncology and targeted therapy.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel kinase inhibitors and other targeted therapeutic agents.
• Oncology Drug Research: Serves as a core scaffold for developing potent and selective compounds in anti-cancer drug discovery programs.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Academic & Contract Research: Employed in university and CRO settings for investigating new biochemical pathways and drug mechanisms.
• Process Development & Scale-up: Utilized in pilot plants and manufacturing facilities to develop robust, scalable synthetic routes for API production.

Basic Information

Product Name	7-Chloro-6-Methoxyquinazolin-4(3H)-One
CAS No.	858238-17-2
Molecular Formula	C9H7ClN2O2
Molecular Weight	210.62 g/mol
Synonyms	7-Chloro-6-methoxy-3,4-dihydroquinazolin-4-one; 7-Chloro-6-methoxy-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 7-chloro-6-methoxy-; 858238-17-2; 7-Chloro-6-methoxyquinazolin-4-ol; 6-Methoxy-7-chloroquinazolin-4(3H)-one
EINECS	Contact for details

Quality Control

Our 7-Chloro-6-Methoxyquinazolin-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete batch data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.