Description

4-Hydroxy-4-(5-(Pyrimidin-2-Yl)Pyridine-2-Yl) Cyclohexanone is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant commercial importance for its role in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitor candidates targeting oncology and inflammatory diseases.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists exploring structure-activity relationships (SAR) in drug discovery programs.
• Biochemical Tool Compound: Used in biochemical assays and high-throughput screening (HTS) to study enzyme inhibition and cellular signaling pathways.
• Pre-clinical Development: Employed in the production of materials for pre-clinical studies, including pharmacokinetic and toxicology evaluations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	4-Hydroxy-4-(5-(Pyrimidin-2-Yl)Pyridine-2-Yl) Cyclohexanone
CAS No.	857651-06-0
Molecular Formula	C15H15N3O2
Molecular Weight	269.30 g/mol
Synonyms	4-(5-(Pyrimidin-2-yl)pyridin-2-yl)cyclohexane-1,4-dione (tautomer); 4-Hydroxy-4-(5-(2-pyrimidinyl)-2-pyridinyl)cyclohexanone; 4-(5-Pyrimidin-2-yl-pyridin-2-yl)-4-hydroxy-cyclohexanone; 4-(5-(Pyrimidin-2-yl)pyridin-2-yl)-4-hydroxycyclohexan-1-one; CAS 857651-06-0; 4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexanone
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-4-(5-(Pyrimidin-2-Yl)Pyridine-2-Yl) Cyclohexanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.