Description

2-Pyrimidinamine, 5-Ethynyl- (9Ci) is a specialized heterocyclic building block featuring a pyrimidine core functionalized with an ethynyl group. This compound is of significant value in advanced organic synthesis and pharmaceutical research, serving as a key intermediate for constructing complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional materials. Its unique structure makes it a versatile precursor for click chemistry and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or cross-linking agent in the creation of advanced polymers and functional organic materials.
• Chemical Biology & Probe Development: The ethynyl group enables bio-conjugation via click chemistry for creating molecular probes and diagnostic tools.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and discovery chemistry.
• Ligand Synthesis: Used to prepare novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Pyrimidinamine, 5-Ethynyl- (9Ci)
CAS No.	857265-74-8
Molecular Formula	C6H5N3
Molecular Weight	119.12 g/mol
Synonyms	5-Ethynylpyrimidin-2-amine; 5-Ethynyl-2-pyrimidinamine; 2-Amino-5-ethynylpyrimidine; 5-Ethynyl-2-aminopyrimidine; 5-Ethynylpyrimidine-2-amine; 2-Pyrimidinamine, 5-ethynyl-; 5-Ethynyl-2-pyrimidinylamine
EINECS	Contact for details

Quality Control

Every batch of 2-Pyrimidinamine, 5-Ethynyl- is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.