Description

Pyrrolo[2,1-F][1,2,4]Triazine-6-Carboxylic Acid, 4-[[1-[(3-Fluorophenyl)Methyl]-1H-Indazol-5-Yl]Amino]-5-Methyl- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Oncology Drug Discovery: Used in research and development programs focused on creating kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Employed as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry & Scale-Up: Supplied for route scouting, process optimization, and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Provided to service organizations supporting the pharmaceutical industry's outsourcing needs.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Item	Detail
Product Name	Pyrrolo[2,1-F][1,2,4]Triazine-6-Carboxylic Acid, 4-[[1-[(3-Fluorophenyl)Methyl]-1H-Indazol-5-Yl]Amino]-5-Methyl-
CAS No.	856667-80-6
Molecular Formula	C23H18FN7O2
Molecular Weight	443.43 g/mol
Synonyms	4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid; 5-Methyl-4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid; UNII-9G2H6T6J8I; 9G2H6T6J8I; BDBM50388879; ZINC000003869952; AKOS025310641; CS-0446243
EINECS	Contact for details

Quality Control

Our Pyrrolo[2,1-F][1,2,4]Triazine-6-Carboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure compliance with research and pharmaceutical intermediate standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.