Description

4-(5-Amino-6-Chloro-4-Pyrimidinyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate critical for modern drug discovery and development. Its value lies in its role as a key building block for synthesizing complex molecules, particularly in the creation of kinase inhibitors and other targeted therapeutics. This compound is essential for research institutions and pharmaceutical manufacturers focused on oncology, immunology, and antiviral drug candidates, where precise chemical architecture is paramount for biological activity.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly kinase inhibitors.
• Oncology Research: Used in the development and scale-up of novel anti-cancer drug candidates targeting specific cellular pathways.
• Biochemical Research: Serves as a key reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in route scouting and process development for the efficient, scalable manufacturing of target molecules.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.
• Antiviral Drug Development: Potential application in the synthesis of compounds targeting viral replication mechanisms.

Basic Information

Product Name	4-(5-Amino-6-Chloro-4-Pyrimidinyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	853679-43-3
Molecular Formula	C13H20ClN5O2
Molecular Weight	313.78 g/mol
Synonyms	tert-Butyl 4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate; 4-(5-Amino-6-chloro-4-pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester; 1-Boc-4-(5-amino-6-chloro-4-pyrimidinyl)piperazine; 5-Amino-6-chloro-4-(1-Boc-piperazin-4-yl)pyrimidine; 6-Chloro-4-(1-Boc-piperazin-4-yl)pyrimidin-5-amine; 853679-43-3; tert-Butyl 4-(5-amino-6-chloro-4-pyrimidinyl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of 4-(5-Amino-6-Chloro-4-Pyrimidinyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured and tested in facilities that follow cGMP principles where applicable. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.