Description

4-[(2-Chloropyrimidin-4-Yl)Oxy]Aniline is a high-purity, advanced pharmaceutical intermediate featuring a chloropyrimidine core linked to an aniline derivative via an ether bond. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted small-molecule therapeutics. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted cancer therapies.
• Agrochemical Research: Used in developing new herbicides and fungicides with specific modes of action.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study biological pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.
• Academic Research: Utilized in university and institutional labs for drug discovery projects and methodological studies.

Basic Information

Product Name	4-[(2-Chloropyrimidin-4-Yl)Oxy]Aniline
CAS No.	853299-33-9
Molecular Formula	C10H8ClN3O
Molecular Weight	221.64 g/mol
Synonyms	4-[(2-Chloro-4-pyrimidinyl)oxy]benzenamine; 4-Amino-2'-chlorodiphenyl ether; 4-(2-Chloropyrimidin-4-yloxy)aniline; 2-Chloro-4-(4-aminophenoxy)pyrimidine; Benzenamine, 4-[(2-chloro-4-pyrimidinyl)oxy]-; 853299-33-9; 4-(2-Chloro-pyrimidin-4-yloxy)-phenylamine
EINECS	Contact for details

Quality Control

Our 4-[(2-Chloropyrimidin-4-Yl)Oxy]Aniline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.