Description

Cbz-2,4-Dichloro-D-Phenylalanine is a protected, non-natural amino acid derivative of significant importance in advanced organic synthesis. This chiral building block is specifically engineered for the construction of complex peptides and peptidomimetics, offering precise stereochemical control. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the 2,4-dichloro-phenylalanine moiety into peptide chains, modifying their biological activity and stability.
• Peptidomimetic Design: Serves as a foundational component for creating peptidomimetics—molecules that mimic peptides but with enhanced metabolic stability and bioavailability.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by acting as a site-specific probe or inhibitor.
• Ligand Development: Useful in the synthesis of specialized ligands for catalysis or molecular recognition studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects for clients in drug discovery.

Basic Information

Product Name	Cbz-2,4-Dichloro-D-Phenylalanine
CAS No.	852838-72-3
Molecular Formula	C17H15Cl2NO4
Molecular Weight	368.21 g/mol
Synonyms	N-Carbobenzoxy-2,4-dichloro-D-phenylalanine; (R)-2-(((Benzyloxy)carbonyl)amino)-3-(2,4-dichlorophenyl)propanoic acid; Z-2,4-Dichloro-D-Phe-OH; Nα-Cbz-2,4-Dichloro-D-phenylalanine; Benzyl (2R)-2-[[(benzyloxy)carbonyl]amino]-3-(2,4-dichlorophenyl)propanoate (related ester); CBZ-D-2,4-Dichloro-Phe; N-CBz-2,4-Dichloro-D-Phenylalanine
EINECS	Contact for details

Quality Control

Our Cbz-2,4-Dichloro-D-Phenylalanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.