Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3,3-Difluoro-3-Phenylpropanoic Acid is a specialized, non-natural amino acid derivative featuring a difluoromethyl group on the β-carbon of the phenylalanine side chain. This compound is a critical building block in modern pharmaceutical research, particularly for the synthesis of peptides and peptidomimetics where enhanced metabolic stability and altered electronic properties are required. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs targeting a wide range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the incorporation of difluorinated phenylalanine analogs into novel active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) as an Fmoc-protected amino acid to create peptides with improved protease resistance and bioavailability.
• Protease Inhibitor Development: Serves as a core structural element in the design of enzyme inhibitors, leveraging the electron-withdrawing and steric properties of the difluoro group.
• Bioconjugation & Probe Synthesis: Employed in the preparation of labeled peptides and molecular probes for biochemical and diagnostic applications.
• Academic & Contract Research: Essential for research institutions and CROs (Contract Research Organizations) exploring structure-activity relationships (SAR) in medicinal chemistry.
• Preclinical Candidate Optimization: Integral to lead optimization stages to fine-tune the physicochemical and pharmacokinetic properties of drug candidates.

Basic Information

Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3,3-Difluoro-3-Phenylpropanoic Acid
CAS No.	852836-39-6
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-3,3-Difluoro-D-phenylalanine; Fmoc-D-F2Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluoro-3-phenylpropanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-difluoro-D-phenylalanine; Fmoc-D-3,3-Difluorophenylalanine; Nα-Fmoc-3,3-difluoro-D-phenylalanine; Fmoc-D-3,3-F2-Phe-OH
EINECS	Contact for details

Quality Control

Our (2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3,3-Difluoro-3-Phenylpropanoic Acid is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive pharmaceutical R&D. Each batch is subjected to comprehensive analytical testing including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity (typically ≥98%), and specific impurities is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. For optimal performance, allow the vial to equilibrate to room temperature before opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.