Description

Ethyl 7-Hydroxy-2-Methyl-3-[3-(Trifluoromethyl)Phenyl]Pyrazolo[1,5-A]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a pyrazolopyrimidine core and a trifluoromethylphenyl group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted therapeutic agents with enhanced metabolic stability and binding affinity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Oncology Drug Development: Serves as a core scaffold for potential kinase inhibitors and other targeted cancer therapies.
• Anti-inflammatory Agent Synthesis: Employed in the synthesis pathway for compounds targeting inflammatory pathways.
• Chemical Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry & Scale-Up: Integral to route scouting and optimization for the commercial-scale manufacturing of complex molecules.

Basic Information

Item	Details
Product Name	Ethyl 7-Hydroxy-2-Methyl-3-[3-(Trifluoromethyl)Phenyl]Pyrazolo[1,5-A]Pyrimidine-6-Carboxylate
CAS No.	852690-95-0
Molecular Formula	C₁₇H₁₄F₃N₃O₃
Molecular Weight	365.31 g/mol
Synonyms	7-Hydroxy-2-methyl-3-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester; Ethyl 7-hydroxy-2-methyl-3-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate; 852690-95-0; Pyrazolo[1,5-a]pyrimidine-6-carboxylic acid, 7-hydroxy-2-methyl-3-[3-(trifluoromethyl)phenyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 7-Hydroxy-2-Methyl-3-[3-(Trifluoromethyl)Phenyl]Pyrazolo[1,5-A]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.