Description

2,2,2-Trifluoro-1-(4-Fluoro-Phenyl)-Ethylamine is a high-purity fluorinated aromatic amine building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into novel molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where fluorine substitution enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Acts as a monomer or functionalization agent for fluorinated polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological mechanisms and diagnostics.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up services for specialized fluorinated compounds.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-Fluoro-Phenyl)-Ethylamine
CAS No.	852443-99-3
Molecular Formula	C8H7F4N
Molecular Weight	193.14 g/mol
Synonyms	1-(4-Fluorophenyl)-2,2,2-trifluoroethanamine; α,α,α-Trifluoro-4-fluoro-phenethylamine; 4-Fluoro-α,α,α-trifluorophenethylamine; 2,2,2-Trifluoro-1-(4-fluorophenyl)ethanamine; (4-Fluorophenyl)(trifluoromethyl)methylamine; 1-(4-Fluorophenyl)-2,2,2-trifluoroethylamine; 4-Fluoro-α-(trifluoromethyl)benzylamine; 852443-99-3
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(4-Fluoro-Phenyl)-Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This amine compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizers and acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.