Description

Pyrido[3,4-D]Pyrimidine-7(6H)-Carboxylic Acid, 4-Chloro-5,8-Dihydro-2-(Methylthio)-, Phenylmethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a key synthetic building block in the development of novel therapeutic agents, particularly kinase inhibitors. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of targeted drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of kinase inhibitor drug candidates for oncology and other therapeutic areas.
• Biochemical Research: Used as a reference standard or a core scaffold in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: Employed in the construction of complex pyrido-pyrimidine derivatives for various chemical and biological investigations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of active pharmaceutical ingredients (APIs) under cGMP conditions.

Basic Information

Product Name	Pyrido[3,4-D]Pyrimidine-7(6H)-Carboxylic Acid, 4-Chloro-5,8-Dihydro-2-(Methylthio)-, Phenylmethyl Ester
CAS No.	852443-96-0
Molecular Formula	C16H14ClN3O2S
Molecular Weight	347.82 g/mol
Synonyms	4-Chloro-5,8-dihydro-2-(methylthio)pyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid benzyl ester; Benzyl 4-chloro-5,8-dihydro-2-(methylthio)-7-oxo-6,7-dihydropyrido[3,4-d]pyrimidine-6-carboxylate; 852443-96-0; Pyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid, 4-chloro-5,8-dihydro-2-(methylthio)-, phenylmethyl ester; 4-Chloro-2-(methylthio)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development and commercial projects with material produced under quality management systems suitable for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.