Description

2-(Chloromethyl)-5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4-Ol is a high-purity, advanced pharmaceutical intermediate belonging to the thienopyrimidine class of heterocyclic compounds. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted therapeutic agents with specific biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Chemical Synthesis: Acts as a versatile scaffold for constructing complex heterocyclic libraries for high-throughput screening.
• Academic Research: Employed in universities and research institutes for studying thienopyrimidine chemistry and its biological interactions.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-(Chloromethyl)-5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4-Ol
CAS No.	852400-39-6
Molecular Formula	C13H8ClFN2OS
Molecular Weight	294.73 g/mol
Synonyms	4-Hydroxy-2-(chloromethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine; 5-(4-Fluorophenyl)-2-(chloromethyl)thieno[2,3-d]pyrimidin-4-ol; 2-(Chloromethyl)-5-(p-fluorophenyl)-4-hydroxythieno[2,3-d]pyrimidine; Thieno[2,3-d]pyrimidin-4-ol, 2-(chloromethyl)-5-(4-fluorophenyl)-; 852400-39-6; FC-1133 (Potential R&D Code)
EINECS	Contact for details

Quality Control

Every batch of 2-(Chloromethyl)-5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4-Ol is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.