Description

1,5-Anhydro-4,6-o-Benzylidene-2,3-Dideoxy-2-[5-Methyl-1H-Pyrimidine-2,4-Dione-1-Yl]-D-Glucitol is a sophisticated nucleoside analogue derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of novel therapeutic agents. Its unique structure, featuring a protected sugar moiety linked to a modified uracil base, makes it a versatile building block in medicinal chemistry. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of antiviral and anticancer drugs, as well as other nucleoside-based treatments.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analogue drugs targeting viral infections and cancer.
• Antiviral Drug Research: Used in R&D for developing therapeutics against viruses such as hepatitis, herpes, and other DNA/RNA viruses.
• Anticancer Agent Development: Serves as a building block for creating chemotherapeutic agents that interfere with DNA/RNA synthesis in tumor cells.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the efficacy and selectivity of drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleoside metabolism.
• Process Chemistry: Acts as a starting material for scaling up the production of complex active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	1,5-Anhydro-4,6-o-Benzylidene-2,3-Dideoxy-2-[5-Methyl-1H-Pyrimidine-2,4-Dione-1-Yl]-D-Glucitol
CAS No.	852235-06-4
Molecular Formula	C19H20N2O6
Molecular Weight	372.37 g/mol
Synonyms	1-(2,3-Dideoxy-4,6-O-benzylidene-D-glucitol-2-yl)-5-methyluracil; 5-Methyl-1-(2,3-dideoxy-4,6-O-benzylidene-D-glucitol-2-yl)uracil; 1,5-Anhydro-4,6-O-benzylidene-2,3-dideoxy-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-glucitol; Benzylidene-protected thymidine glucitol derivative; Nucleoside glucitol intermediate; Thymine glucitol benzylidene acetal; CAS 852235-06-4
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates. Specifications can be aligned with client requirements for specific drug development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.