Description

4,6-Dichloro-5-Methyl-2-(Trifluoromethyl)Pyrimidine is a high-value, multi-functional heterocyclic building block characterized by its reactive halogen and trifluoromethyl substituents. This compound is essential for the synthesis of advanced agrochemicals and pharmaceuticals, where it serves as a key intermediate for introducing the trifluoromethyl group, a moiety known to enhance biological activity, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development teams in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethylpyrimidine core.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers, liquid crystals, and electronic materials requiring specific fluorine-containing motifs.
• Cross-Coupling Reactions: The chlorine atoms provide excellent handles for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create diverse chemical libraries.
• Nucleophilic Substitution: Reacts readily with various nucleophiles (amines, alkoxides, thiols) to generate a wide array of 4,6-disubstituted pyrimidine derivatives for screening.

Basic Information

Product Name	4,6-Dichloro-5-Methyl-2-(Trifluoromethyl)Pyrimidine
CAS No.	852062-35-2
Molecular Formula	C6H3Cl2F3N2
Molecular Weight	231.00 g/mol
Synonyms	2-(Trifluoromethyl)-4,6-dichloro-5-methylpyrimidine; 5-Methyl-4,6-dichloro-2-(trifluoromethyl)pyrimidine; 4,6-Dichloro-5-methyl-2-trifluoromethylpyrimidine; Pyrimidine, 4,6-dichloro-5-methyl-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-5-Methyl-2-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our production adheres to cGMP principles where applicable, ensuring consistency, traceability, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.