Description

4,6-Dichloro-5-Methoxy-2-Methylpyrimidine is a high-purity halogenated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its versatile reactivity, particularly as a key intermediate for constructing complex heterocyclic systems found in pharmaceuticals and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its pyrimidine core for biological activity.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and process chemistry research to explore new chemical entities.
• Material Science: Potential intermediate for creating specialized polymers, liquid crystals, or organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4,6-Dichloro-5-Methoxy-2-Methylpyrimidine
CAS No.	851986-00-0
Molecular Formula	C6H6Cl2N2O
Molecular Weight	193.03 g/mol
Synonyms	5-Methoxy-2-methyl-4,6-dichloropyrimidine; 2-Methyl-4,6-dichloro-5-methoxypyrimidine; 4,6-Dichloro-5-methoxy-2-methyl-pyrimidine; 851986-00-0; Pyrimidine, 4,6-dichloro-5-methoxy-2-methyl-
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-5-Methoxy-2-Methylpyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.