Description

6-Bromo-8-Cyclopentyl-5-Methyl-2-(5-(Piperazin-1-Yl)Pyridin-2-Ylamino)Pyrido[2,3-D]Pyrimidin-7(8H)-One is a high-purity, advanced pharmaceutical intermediate designed for research and development in targeted therapeutic areas. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in the synthesis of novel kinase inhibitors and other biologically active molecules. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and CROs (Contract Research Organizations) engaged in oncology and signal transduction pathway research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective kinase inhibitors for therapeutic development.
• Oncology Research: Used in the discovery and optimization of drug candidates targeting specific cancer pathways.
• Biochemical Tool Compound: Serves as a reference standard or probe in enzymatic assays and cellular studies to understand biological mechanisms.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore modifications and improve drug-like properties.
• Preclinical Development: Utilized in the production of batches for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Custom Synthesis: Acts as a starting material for the contract manufacturing of specialized APIs (Active Pharmaceutical Ingredients) under cGMP conditions.

Basic Information

Product Name	6-Bromo-8-Cyclopentyl-5-Methyl-2-(5-(Piperazin-1-Yl)Pyridin-2-Ylamino)Pyrido[2,3-D]Pyrimidin-7(8H)-One
CAS No.	851067-56-6
Molecular Formula	C27H31BrN8O
Molecular Weight	563.50 g/mol
Synonyms	851067-56-6; 6-Bromo-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one; PF-06463922 Intermediate; Lorlatinib Intermediate; ALK/ROS1 Inhibitor Intermediate; 6-Bromo-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
EINECS	Contact for details

Quality Control

Our 6-Bromo-8-Cyclopentyl-5-Methyl-2-(5-(Piperazin-1-Yl)Pyridin-2-Ylamino)Pyrido[2,3-D]Pyrimidin-7(8H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are provided with every shipment. We support development with custom purity grades and specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.