Description

Fmoc-Amino-(Peg)n-Acid CAS NO 850312-72-0 is a specialized polyethylene glycol (PEG)-based building block featuring an Fmoc-protected amino group and a terminal carboxylic acid. This bifunctional linker is critical for introducing hydrophilic spacers and enhancing solubility in peptide and bioconjugate synthesis. It is primarily needed by research institutions and pharmaceutical companies engaged in developing peptide-drug conjugates, diagnostic probes, and advanced biomaterials.

Application

• As a hydrophilic spacer in the solid-phase synthesis of PEGylated peptides and proteins.
• Conjugation reagent for creating fluorescent or biotinylated probes with improved aqueous solubility.
• Building block for synthesizing drug-linker payloads in Antibody-Drug Conjugate (ADC) development.
• Intermediate in the preparation of functionalized hydrogels and biocompatible polymers.
• Used to modify surfaces for biosensor and microarray applications.
• Critical reagent in prodrug design to enhance pharmacokinetic properties.

Basic Information

Product Name	Fmoc-Amino-(Peg)n-Acid
CAS No.	850312-72-0
Molecular Formula	C23H27NO7 (for n=2, example)
Molecular Weight	429.47 g/mol (for n=2, example)
Synonyms	Fmoc-NH-PEGn-COOH; N-α-Fmoc-amino-PEGn-acid; Fmoc-8-amino-3,6-dioxaoctanoic acid (for n=2); Fmoc-PEGn-NH2 linker; 9-Fluorenylmethyl N-(carboxymethylpolyoxyethylene)carbamate; Poly(ethylene glycol), α-(9-fluorenylmethyloxycarbonylamino)-ω-carboxy; Fmoc-AEEA-AEEA-acid; Fmoc-PEG Acid
EINECS	Contact for details

Quality Control

Our Fmoc-Amino-(Peg)n-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.