Description

tert-Butyl n-(2-Chloropyrimidin-4-Yl)Carbamate is a high-purity, protected pyrimidine derivative of significant importance in advanced organic synthesis. This compound serves as a versatile and critical building block for the development of complex pharmaceutical molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for novel therapeutic agents.
• Agrochemical Synthesis: Serves as a building block for creating novel pesticides and herbicides with specific modes of action.
• Chemical Biology: Employed in the development of molecular probes and tool compounds for biological target validation.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Nucleic Acid Chemistry: Acts as a modified base analog in the research and development of oligonucleotide-based therapies.

Basic Information

Product Name	tert-Butyl n-(2-Chloropyrimidin-4-Yl)Carbamate
CAS No.	849751-48-0
Molecular Formula	C9H12ClN3O2
Molecular Weight	229.66 g/mol
Synonyms	Boc-2-Chloro-4-aminopyrimidine; tert-Butyl (2-Chloropyrimidin-4-yl)carbamate; 2-Chloro-4-((tert-butoxycarbonyl)amino)pyrimidine; 4-((tert-Butoxycarbonyl)amino)-2-chloropyrimidine; 2-Chloro-4-aminopyrimidine N-Boc derivative; N-Boc-2-chloro-4-aminopyrimidine; 849751-48-0; 2-Chloro-4-pyrimidinamine, N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(2-Chloropyrimidin-4-Yl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for pre-clinical and clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.