Description

3-(2-Chloroethyl)-2-Methyl-9-Hydroxy-6,7,8,9-Tetrahydro-4H-Pyrido[1,2-a]Pyrimidin-4-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for central nervous system (CNS) and other specialized therapeutic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates and novel APIs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• CNS Drug Development: Serves as a core scaffold for compounds targeting neurological and psychiatric disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and pharmacological mechanisms.
• Process Chemistry: Employed in route scouting and scale-up optimization for efficient commercial manufacturing.

Basic Information

Product Name	3-(2-Chloroethyl)-2-Methyl-9-Hydroxy-6,7,8,9-Tetrahydro-4H-Pyrido[1,2-a]Pyrimidin-4-One Hydrochloride
CAS No.	849727-63-5
Molecular Formula	C12H16ClN3O2•HCl
Molecular Weight	306.19 g/mol
Synonyms	9-Hydroxy-3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride; 3-(2-Chloroethyl)-2-methyl-9-hydroxy-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one HCl; 849727-63-5; UNII-6J8W7QK5UM; 6J8W7QK5UM; 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-hydroxy-3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-, hydrochloride (1:1); SCHEMBL21806427
EINECS	Contact for details

Quality Control

Our 3-(2-Chloroethyl)-2-Methyl-9-Hydroxy-6,7,8,9-Tetrahydro-4H-Pyrido[1,2-a]Pyrimidin-4-One Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of pharmaceutical R&D and pre-clinical development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.