Description

tert-Butyl-7-[4-(4-Fluorophenyl)-6-Isopropyl-2-Methylsulfonylpyrimidin-5-Yl]-(3R,5S)-Isopropylidene-(E)-6-Heptenoate is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the statin class of cholesterol-lowering drugs, due to its role as a key chiral building block. It is essential for research and development laboratories, process chemists, and large-scale manufacturers in the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for efficient API production.

Application

• Key Intermediate in Statin Synthesis: Serves as a crucial chiral precursor in the manufacturing of Atorvastatin (Lipitor) and related HMG-CoA reductase inhibitors.
• Pharmaceutical R&D: Used in process development and optimization for new drug candidates targeting cholesterol management.
• Fine Chemical Production: Employed in the synthesis of other complex, stereospecific organic molecules requiring the (3R,5S) dihydroxyheptenoate side chain.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant API production.
• Academic Research: Utilized in university and institutional laboratories studying synthetic organic chemistry and medicinal chemistry pathways.

Basic Information

Product Name	tert-Butyl-7-[4-(4-Fluorophenyl)-6-Isopropyl-2-Methylsulfonylpyrimidin-5-Yl]-(3R,5S)-Isopropylidene-(E)-6-Heptenoate
CAS No.	849470-63-9
Molecular Formula	C30H39FN2O5S
Molecular Weight	558.71 g/mol
Synonyms	(3R,5S)-tert-Butyl 7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate Isopropylidene Derivative; (E)-tert-Butyl (3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate Isopropylidene Acetal; Atorvastatin tert-Butyl Ester Key Intermediate; tert-Butyl (3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-methylsulfonylpyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate Acetonide; (3R,5S)-Isopropylidene Atorvastatin tert-Butyl Ester Intermediate; 849470-63-9; Fluorophenyl Isopropyl Methylsulfonyl Pyrimidine Heptenoate Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl-7-[4-(4-Fluorophenyl)-6-Isopropyl-2-Methylsulfonylpyrimidin-5-Yl]-(3R,5S)-Isopropylidene-(E)-6-Heptenoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the stringent specifications required for pharmaceutical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to support regulatory filings (e.g., DMF, CEP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (3R,5S)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.