Description

4-(4-Fluorophenyl)-5-Formyl-6-Isopropyl-2-Methylsulfonylpyrimidine is a high-purity, functionalized pyrimidine derivative, identified by CAS number 849470-61-7, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the strategic combination of a formyl group and a methylsulfonyl substituent on the pyrimidine core, which provides versatile handles for further chemical elaboration. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecules for active ingredient discovery and development.

Application

This specialized pyrimidine building block is designed for precision synthesis in advanced R&D and manufacturing. Key application areas include:

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Active Ingredient Development: Used to construct heterocyclic cores for new herbicides, fungicides, and insecticides.
• Chemical Research & Development: A versatile scaffold for exploring structure-activity relationships (SAR) and synthesizing libraries of novel compounds for screening.
• Material Science Precursor: Potential use in the development of specialty chemicals and functional materials requiring tailored organic structures.
• Contract Manufacturing & Custom Synthesis: Supplied to CDMOs for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	4-(4-Fluorophenyl)-5-Formyl-6-Isopropyl-2-Methylsulfonylpyrimidine
CAS No.	849470-61-7
Molecular Formula	C₁₆H₁₅FN₂O₃S
Molecular Weight	334.36 g/mol
Synonyms	5-Formyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methylsulfonyl)pyrimidine; 2-Methylsulfonyl-4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidine; 849470-61-7; 4-(p-Fluorophenyl)-5-formyl-6-isopropyl-2-methylsulfonylpyrimidine; 6-Isopropyl-4-(4-fluorophenyl)-5-formyl-2-methylsulfonylpyrimidine
EINECS	Contact for details

Quality Control

Our production of 4-(4-Fluorophenyl)-5-Formyl-6-Isopropyl-2-Methylsulfonylpyrimidine adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical specifications. Our quality commitment supports applications requiring research-grade to cGMP-compliant materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider packaging under an inert atmosphere like nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.