Description

4-(4-Fluorophenyl)-5-Hydroxymethyl-6-Isopropyl-2-Methylsulfonylpyrimidine CAS NO 849470-59-3 is a high-purity, functionalized pyrimidine derivative characterized by its fluorophenyl and methylsulfonyl substituents. This compound is a critical advanced pharmaceutical intermediate (API) valued for its role in constructing complex molecular architectures. It is primarily sought by pharmaceutical R&D and manufacturing sectors for the synthesis of novel active ingredients, particularly in therapeutic areas requiring targeted biological activity.

Application

This specialized pyrimidine building block is engineered for high-value synthetic applications. Key uses include:

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorophenyl group contributes to biological efficacy and environmental stability.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials requiring specific aromatic heterocyclic cores.

Basic Information

Product Name	4-(4-Fluorophenyl)-5-Hydroxymethyl-6-Isopropyl-2-Methylsulfonylpyrimidine
CAS No.	849470-59-3
Molecular Formula	C16H19FN2O3S
Molecular Weight	338.40 g/mol
Synonyms	4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)-2-(methylsulfonyl)pyrimidine; 2-Methylsulfonyl-4-(4-fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidine; 5-(Hydroxymethyl)-4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine; CAS 849470-59-3; Fluorophenyl Hydroxymethyl Isopropyl Methylsulfonyl Pyrimidine
EINECS	Contact for details

Quality Control

Our production of 4-(4-Fluorophenyl)-5-Hydroxymethyl-6-Isopropyl-2-Methylsulfonylpyrimidine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and rigorous control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure full traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.