Description

[Trp3,Arg5]-Ghrelin (1-5) (Human, Rat) is a synthetic peptide fragment of the appetite-regulating hormone ghrelin, featuring specific amino acid substitutions at positions 3 and 5. This modified sequence is of significant value for targeted research into growth hormone secretagogue receptor 1a (GHSR-1a) activity and metabolic pathways. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in endocrinology, obesity, and metabolic disorder studies.

Application

• Biochemical Research: Used as a specific ligand for studying the binding affinity and signaling mechanisms of the GHSR-1a receptor.
• Structure-Activity Relationship (SAR) Studies: Serves as a key analog to investigate the impact of Trp and Arg substitutions on ghrelin's biological activity and stability.
• In Vitro Assay Development: Employed in the development and validation of cell-based assays for screening potential ghrelin receptor agonists or antagonists.
• Metabolic Pathway Analysis: A tool for probing the role of specific ghrelin fragments in appetite stimulation, growth hormone release, and energy homeostasis.
• Reference Standard: Acts as a high-purity analytical standard for peptide quantification and quality control in related research.

Basic Information

Product Name	[Trp3,Arg5]-Ghrelin (1-5) (Human, Rat)
CAS No.	848442-59-1
Molecular Formula	C34H48N12O6
Molecular Weight	720.83 g/mol
Synonyms	Trp3-Arg5-Ghrelin(1-5); H-Gly-Ser-Trp-Arg-Phe-OH; Ghrelin (1-5) amide analog; GHRP-6 fragment analog; Growth hormone secretagogue peptide fragment; [Trp3,Arg5]-Ghrelin (1-5); Human/Rat Ghrelin pentapeptide analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of [Trp3,Arg5]-Ghrelin (1-5) (Human, Rat) undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing purity, content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.