Description

1,5-Dioxo-4-Propyl-2,3,4,5-Tetrahydropyrrolo[1,2-A]Quinazoline-3A(1H)-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and complex generic drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel quinazoline and pyrroloquinazoline-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis: Used in advanced multi-step synthetic routes to construct complex fused heterocyclic systems for specialty chemicals.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Potential use as a precursor for developing enzyme inhibitors or molecular probes due to its specific structural features.

Basic Information

Product Name	1,5-Dioxo-4-Propyl-2,3,4,5-Tetrahydropyrrolo[1,2-A]Quinazoline-3A(1H)-Carboxylic Acid
CAS No.	848052-91-5
Molecular Formula	C16H16N2O4
Molecular Weight	300.31 g/mol
Synonyms	4-Propyl-1,5-dioxo-2,3,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3a(1H)-carboxylic acid; 3a-Carboxy-4-propyl-1,5-dioxo-1,3a,4,5-tetrahydropyrrolo[1,2-a]quinazoline; Pyrrolo[1,2-a]quinazoline-3a(1H)-carboxylic acid, 2,3,4,5-tetrahydro-1,5-dioxo-4-propyl-; CAS 848052-91-5; 4-n-Propyl-1,5-dioxo-1,3a,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3a-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1,5-Dioxo-4-Propyl-2,3,4,5-Tetrahydropyrrolo[1,2-A]Quinazoline-3A(1H)-Carboxylic Acid is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Production adheres to ICH guidelines, and the material is suitable for use in GMP environments. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.