Description

1-[4-(Difluoromethoxy)-3-Methoxyphenyl]Methanamine is a high-purity aromatic amine derivative featuring a difluoromethoxy substituent, a key structural motif in advanced chemical synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated aromatic systems into their molecular designs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used as a building block for developing advanced pesticides and herbicides where the difluoromethoxy group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and functional materials with specific electronic or surface properties.
• Fluorinated Compound Library Synthesis: Essential for medicinal chemistry and discovery chemistry programs focused on expanding fluorinated chemical space for screening.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Item	Detail
Product Name	1-[4-(Difluoromethoxy)-3-Methoxyphenyl]Methanamine
CAS No.	847744-28-9
Molecular Formula	C9H11F2NO2
Molecular Weight	203.19 g/mol
Synonyms	4-(Difluoromethoxy)-3-methoxybenzylamine; [4-(Difluoromethoxy)-3-methoxyphenyl]methanamine; 3-Methoxy-4-(difluoromethoxy)benzylamine; 1-(4-(Difluoromethoxy)-3-methoxyphenyl)methanamine; α-Amino-4-(difluoromethoxy)-3-methoxy toluene; (4-(Difluoromethoxy)-3-methoxyphenyl)methylamine
EINECS	Contact for details

Quality Control

Our 1-[4-(Difluoromethoxy)-3-Methoxyphenyl]Methanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets stringent specifications for use in sensitive applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, and we support development under cGMP standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.