Description

2-Iodo-4,5-Difluoroaniline is a high-purity, halogenated aniline derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique combination of iodine and fluorine substituents, which impart distinct electronic and steric properties for creating complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and iodine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for constructing biaryl systems and complex conjugated molecules.
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized halogenated dyes and pigments with unique color fastness and spectral properties.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for creating custom compound libraries in drug discovery programs.

Basic Information

Product Name	2-Iodo-4,5-Difluoroaniline
CAS No.	847685-01-2
Molecular Formula	C6H4F2IN
Molecular Weight	255.01 g/mol
Synonyms	4,5-Difluoro-2-iodoaniline; 2-Iodo-4,5-difluorobenzenamine; Benzenamine, 4,5-difluoro-2-iodo-; 4,5-Difluoro-2-iodophenylamine; 2-Amino-4,5-difluoroiodobenzene; 1-Amino-2-iodo-4,5-difluorobenzene; 847685-01-2 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Iodo-4,5-Difluoroaniline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC-MS, and NMR for identity confirmation and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with each shipment. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, handling should be performed under subdued light or amber glass containers to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.