Description

7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine, 4-Chloro-5-Iodo-7-(2-C-Methyl-β-D-Ribofuranosyl)- is a sophisticated nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate for the creation of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular kinases. Pharmaceutical companies, biotechnology firms, and advanced contract research organizations (CROs) engaged in nucleoside-based drug discovery are the primary users of this high-value chemical.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of next-generation antiviral drugs, including potential treatments for hepatitis C (HCV) and other RNA viruses.
• Anticancer Agent Development: Serves as a precursor in the research and synthesis of nucleoside analogs designed to inhibit tumor cell proliferation.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide metabolism.
• Prodrug Synthesis: Employed in the design and creation of prodrugs to enhance the bioavailability and targeting of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Item	Details
Product Name	7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine, 4-Chloro-5-Iodo-7-(2-C-Methyl-β-D-Ribofuranosyl)-
CAS No.	847551-58-0
Molecular Formula	C12H13ClIN3O4
Molecular Weight	425.61 g/mol
Synonyms	4-Chloro-5-iodo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 2-Amino-4-chloro-5-iodo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-5-iodo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-5-iodo-7-(2-C-methyl-β-D-ribofuranosyl)-; 4-Chloro-5-iodo-2'-C-methyl-7-deaza-adenosine intermediate; Nucleoside analog intermediate 847551-58-0
EINECS	Contact for details

Quality Control

Our 7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine, 4-Chloro-5-Iodo-7-(2-C-Methyl-β-D-Ribofuranosyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with research-grade and potential cGMP standards for pharmaceutical intermediates. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and spectral data (NMR, MS) are provided to guarantee traceability and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.