Description

(R)-1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of enantiomerically pure active pharmaceutical ingredients (APIs), where its defined stereochemistry is paramount for biological activity. It is primarily required by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for creating novel therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular research.
• Agrochemical Synthesis: Used in the development of advanced, stereoselective pesticides and herbicides.
• Asymmetric Catalysis: Employed as a ligand precursor or chiral auxiliary in catalytic processes to induce stereoselectivity.
• Chemical Research & Development: Serves as a valuable building block in academic and industrial labs for exploring new chemical entities and reaction pathways.
• Process Chemistry & Scale-up: Utilized in the optimization and commercial-scale manufacturing of chiral target molecules.

Basic Information

Product Name	(R)-1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride
CAS No.	847448-32-2
Molecular Formula	C9H10F2N•HCl
Molecular Weight	205.64 (free base) / 242.10 (HCl salt)
Synonyms	(R)-1-(3,4-Difluorophenyl)-1-propanamine hydrochloride; (R)-3',4'-Difluoropropiophenone amine hydrochloride; (R)-1-Amino-1-(3,4-difluorophenyl)propane hydrochloride; (R)-3,4-Difluoro-α-ethylbenzylamine hydrochloride; (R)-α-Ethyl-3,4-difluorobenzylamine hydrochloride; (R)-1-(3,4-Difluorophenyl)propylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(3,4-Difluorophenyl)Propan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.